Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Studies on intestinal passage of flumequine and oxytetracycline-loaded MIL-100 (Fe) in the presence of divalent ions

Fatma Ben Ayed^1,2,4 , Godefroy Mamadou², Hanae Naceiri Mrabti^2,3, Nicolas Limas-Nzouzi², Bruno Eto², Saad Saguem¹

¹Laboratory of Professional Metabolic Biophysics and Toxicology Environment, Faculty of Medicine, University Of Sousse, Hamed El Karoui Avenue, 4000 Sousse, Tunisia; ²TransCell-Lab Laboratory, Faculty of Medicine Xavier Bichat, University of Paris Diderot â€“ Paris 7, 16 rue Henri Huchard 75890 Paris, France; ³Faculty of Medicine and Pharmacy, Laboratory of Pharmacology and Toxicology, University of Mohammed V, Av. Mohamed Belarbi El Alaoui, 6203 Rabat-Instituts, Maroc; ⁴Faculty of Sciences, Bizerte, University of Carthage, 7021 Jarzouna, Tunisia.

For correspondence:- Fatma Ayed Email: go.mad289@gmail.com

Accepted: 15 June 2018 Published: 28 July 2018

Citation: Ayed FB, Mamadou G, Mrabti HN, Limas-Nzouzi N, Eto B, Saguem S. Studies on intestinal passage of flumequine and oxytetracycline-loaded MIL-100 (Fe) in the presence of divalent ions. Trop J Pharm Res 2018; 17(7):1295-1299 doi: 10.4314/tjpr.v17i7.10

© 2018 The authors.
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Abstract

Purpose: To compare the intestinal absorption of flumequine (FLM) and oxytetracycline (OTC) in encapsulated and non-encapsulated forms in the presence of divalent ions.

Methods: MIL-100 (Fe) nanoparticles were synthesized under hydrothermal conditions from a mixture of iron carboxylate and trimesic acid (organic linker), and then used to encapsulate OTC and FLM. Permeation of the various formulations through the mouse jejunum was evaluated in Ussing chamber.

Results: There was significant (p F6; 0.05) increase in the intestinal flux of encapsulated OTCs (OTC-NPs, 0.072 ± 0.016 μg/h/cm²), compared to that of non-encapsulated OTCs (0.021 ± 0.05 μg/h/cm²). Moreover, the intestinal flux of encapsulated FLMs (FLM-NPs, 0.045 ± 0.006 μg/h/cm²) was significantly higher than that of non-encapsulated FLMs (0.004 ± 0.0008 μg/ h/cm², p F6; 0.05).

Conclusion: The intestinal flux of encapsulated antibiotics is significantly enhanced in the presence of MIL-100 (Fe), thereby preventing their chelation by divalent ions in solution, and thus improving their intestinal absorption.

Keywords: MIL-100 (Fe), Intestinal bioavailability, Mice, Oxytetracycline, Flumequine